Vitamin A in Skin Innate Immunity and Microbiome: A Narrative Review

22 July 2026
Ali Alawadhi
Vitamin A in Skin Innate Immunity and Microbiome: A Narrative Review

Abstract

  • Background

Vitamin A is a fat-soluble vitamin that plays an important role in skin immunity. Deficiencies in vitamin A have been linked to impaired immune response and increased susceptibility to skin infections and inflammatory skin disease.

  • Results

This narrative review summarizes recent primary evidence that elucidates the role of vitamin A and its derivatives on innate immune regulators through mechanisms that promote skin immunity and sustain the skin microbiome.

  • Conclusions

Adequate vitamin A status is essential for optimizing cutaneous innate immune defenses and maintaining a balanced skin microbiome to prevent inflammatory skin conditions and infections.



https://pubmed.ncbi.nlm.nih.gov/33494277/