Abstract
- Background
Constipation is among the most common health impairments in Western countries. This study aimed to determine the effect of the chicory-derived fermentable dietary fiber Orafti Inulin on stool frequency in healthy subjects with constipation, adhering to recent guidance documents for investigating bowel function.
- Methods
A randomized, double-blind, placebo-controlled, cross-over design with a 2-week wash-out phase was conducted. Each study period comprised a run-in phase followed by 4 weeks of daily intake of 3 times 4 grams of inulin or maltodextrin as a placebo. Forty-four healthy volunteers with constipation documented their stool frequency and consistency, gastrointestinal characteristics, and quality of life.
- Results
Consumption of Orafti Inulin significantly increased stool frequency compared to placebo, showing a higher median of stools per week. This improvement was accompanied by a softening of stools and a positive trend toward higher satisfaction compared to the placebo group.
- Conclusions
Orafti Inulin was effective in volunteers with chronic constipation and significantly improved overall bowel function.
https://www.tandfonline.com/doi/full/10.1080/09637486.2016.1212819